Paget's disease and bone remodeling
Paget disease is a common condition characterized by a disruption of the body's normal bone recycling process. Symptoms include bone or joint pain, tenderness or redness, problems with balance, numbness or tingling in limbs, sciatica pain, headaches, loss of vision, and hearing loss.
Paget or Paget's disease of bone is a common condition characterized by a disruption of the body's normal bone recycling process. It is the second most common type of bone disease after osteoporosis.
Your bones are typically in a constant state of change, with new bone replacing old regularly. With Paget’s disease, your body breaks down older bone more quickly than your body can replace it with new bone. Around 1% of adults in the U.S. have Paget’s disease.
The disease is more common in older adults and those with a family history of Paget’s disease. It typically affects the bones of the pelvis, skull, legs—femur, tibia—and spine. Complications of the disease may lead to fractures, bone pain, and deformities.
Signs and symptoms of Paget disease of bone
Many people with Paget’s disease show no symptoms and have no outward signs of the disease. They may also mistake any symptoms they are experiencing for arthritis. People with Paget’s disease may notice some of the following signs:
Bone or joint pain
One of Paget’s disease's most common symptoms is pain in the bones and inflammation and swelling in joints of the affected region of the body.
Tenderness or redness in the affected area
Affected regions of the body may show outward physical signs such as tenderness or redness of the skin due to increased blood flow. These areas may also feel warm to the touch.
Problems with balance
Individuals with Paget’s disease may experience problems with balance associated with the restriction of a normal range of movement.
Numbness or tingling in limbs
As Paget’s disease progresses, it will often lead to deformations in bone growth. When these deformations occur along your spinal column, the spinal nerve roots may experience pressure, leading to numbness and tingling in the limbs, neck, and shoulders. This numbness and tingling are known as peripheral neuropathy.
Sciatica pain begins along the spine and moves downward through the leg muscles.
Headaches, loss of vision, and hearing loss
Individuals with Paget’s disease in the skull often experience headaches. In some cases, loss of vision and hearing has been experienced.
Causes of Paget’s disease
Scientists don’t know exactly what causes Paget’s disease. However, environmental factors such as prior breaks or bone injury early in life may make you more susceptible. You’re more likely to develop it if you have a family history of Paget’s disease — scientists theorize that several genes are linked to the disease.