Neurofibromatosis type 2 (NF2)
Neurofibromatosis type 2 (NF2), also known as bilateral acoustic neurofibromatosis (NF), is less common than neurofibromatosis type 1 (NF1) and is usually diagnosed in early adulthood. NF2 mostly causes tumors in the central nervous system and vestibulocochlear nerves that control hearing and balance.
People with NF2 may develop:
- Schwannomas: These are tumors of the Schwann cell (which produce a sheath that covers and protects the peripheral nerves).
- Auditory neuroma: Most people with NF2 develop tumors on the nerve that
- processes hearing. As the tumors grow bigger, it leads to progressive hearing loss.
- Meningioma: It is a tumor that arises in the tissue covering the brain and spinal cord.
- Ependymoma: It is a tumor that arises within the spinal cord.
- Visual problems: Cataracts or changes appear at an early age.
- Peripheral neuropathy: Individuals with NF2 may develop problems with nerve function leading to numbness and weakness in the arms and legs with or without muscle loss.
- Other complications:
- Tinnitus or ringing in the affected ear(s)
- Facial pain/numbness, weakness, and sometimes paralysis
- Loss of balance, dizziness, and vertigo