Causes of cancer
Cancer is caused by changes (mutations) in the DNA within the cells. The DNA inside the cell is packaged into many individual genes, each of which contains a set of instructions telling the cell what functions to perform and how to grow and divide. Errors in the instructions can cause the cell to stop its normal function and may allow it to become cancerous.
A gene mutation can instruct a healthy cell to
- Allow rapid growth
- Fail to stop uncontrolled cell growth
- Make mistakes when repairing DNA errors
Nonmodifiable risk factors include
- Genetic inheritance: Many types of cancer run in the family. The reason may be a faulty gene. For example, BRCA mutation is associated with familial breast cancer.
- Familial cancer syndrome: Some types of syndrome such as Von Hippel–Lindau and familial polyposis coli may be responsible for cancer development in the family.
- Age: As a rule, the risk of cancer increases as you age. This may be because of the inability of a mutated cell to repair itself in old age.
Exposure to any predisposing factors (modifiable risk factors) such as
- Radiation exposure (diagnostic, occupational or therapeutic)
- Viruses (human papillomavirus)
- Carcinogens (cancer-causing chemicals such as many industrial solvents [benzene])
- Heavy metals (arsenic, lead and cadmium blamed for kidney cancer and some bone cancer)
- Hormonal influence (prostate cancer is often androgen-dependent)
- Chronic inflammation (Crohn’s disease or ulcerative colitis and colon cancer)
- Environmental pollution (radon and lung cancer)
- Exposure to ultraviolet (UV) light and skin cancer
- It is prudent to remember that we are yet to find out what exactly leads to failure in the cell division and replication that leads to cancer. Having a risk factor does not mean you will get the cancer. Similarly, you may get a certain type of cancer even in absence of any risk factor.